Lupus erythematosus
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References
Å identifisere og klassifisere cutaneous lupus erythematosus (CLE) utgjør diagnostiske utfordringer, og skiller den fra systemic lupus erythematosus med hudinvolvering. Nyere studier kaster lys over genetiske, miljømessige og immunologiske faktorer som ligger til grunn for CLE. Medikamentinduksjon har spesifikt dukket opp som en av de viktigste triggerne for CLE. Behandling involverer aktuelle og systemiske terapier, inkludert lovende biologiske midler (belimumab, rituximab, ustekinumab, anifrolumab, BIIB059) , med demonstrert effekt i kliniske studier.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Cutaneous lupus erythematosus (CLE) dekker ulike hudproblemer, hvorav noen kan knyttes til bredere helseproblemer. Det er kategorisert i forskjellige typer, for eksempel acute CLE (ACLE) , sub-acute CLE (SCLE) , and chronic CLE (CCLE) . CCLE består av discoid lupus erythematosus (DLE) , LE profundus (LEP) , chilblain cutaneous lupus, and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Lupus erythematosus er en gruppe autoimmune sykdommer som kan påvirke ulike deler av kroppen. Noen typer, som systemic lupus erythematosus (SLE) , påvirker flere organer, mens andre, som cutaneous lupus erythematosus (CLE) , hovedsakelig påvirker huden. Vi kategoriserer ulike typer CLE basert på en blanding av kliniske tegn, vevsundersøkelser og blodprøver, men det er mye variasjon mellom individer. Hudproblemer utvikler seg ofte på grunn av faktorer som eksponering for sollys, røyking eller visse medisiner.
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Årsaken til lupus erythematosus er ikke klar. Blant eneggede tvillinger, hvis den ene er rammet, er det 24 % sjanse for at den andre også vil være det. Kvinnelige kjønnshormoner, sollys, røyking, vitamin D-mangel og visse infeksjoner antas også å øke risikoen.
Behandlinger kan omfatte NSAIDs, kortikosteroider, immunsuppressiva, hydroksyklorokin og metotreksat. Selv om kortikosteroider er effektive, resulterer langvarig bruk i bivirkninger.